Introducción: 

SARS-CoV-2 vaccination showed to be effective in avoiding severe disease. Different platform vaccines include adenoviral vectors, attenuated virus, mRNA and viral-like particles. Humoral response after boostering subjects with complete Sputnik V using a different platform vaccine is poorly described.

Objetivos: 

To evaluate humoral response with Sputnik V vaccine in health care workers (HCW). To compare humoral response in HCW with complete Sputnik V vaccine followed by homologous or heterologous platform booster.

Materiales y métodos: 

A prospective observational cohort study in HCW with complete Sputnik V vaccine (2 doses) was conducted from February-2021 to June-2022.

Resultados: 

Serum samples (n=634) from 134 HCWs were evaluated. HCW median age was 40 years old, 65% were female and none was immunocompromised. Most HCW (77 %) were naive of SARS-CoV-2 infection at enrollment.

Discusión / Conclusiones: 

Complete Sputnik V scheme was highly immunogenic eliciting 100% seroconversion among our HCW. Heterologous platform booster elicited significantly higher humoral response than homologous platform booster among HCW with complete Sputnik V.